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Cell Biology (Wenner-Gren Institute)
Head of unit:
Dr Claes Andreason
Arrheniuslab F 4, Svante Arrheniusväg 16 - 18
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Activation of B lymphocytes: adhesion, motility and regulation of Ig production
B lymphocytes constitute an important part of the adaptive immune defense. The cells change adhesive and migratory properties, switch immunoglobulin (Ig) class and somatically mutate their V-genes during antigen activation in vivo. I wish to elucidate the mechanisms of B cell activation. Specific ...
ATP-dependent chromatin remodelling complexes in cancer development
ATP-dependent Chromatin Remodelling Complexes in Cancer Development
ATP-dependent Chromatin Remodelling Complexes in Transcription and other nuclear processes
Chromatin plays an important role in nuclear processes, as it constitutes a barrier for factors invovled in processes that need to gain access to DNA. Each cell has several proteins complexes that change the chromatin structure and play roles in gene regulation, replication, DNA repair, ...
Cellular functions of the Hsp70 chaperone machinery
Proteiner har invecklade tredimensionella strukturer som krävs för deras funktion i cellen. När proteiner veckas till sina aktiva strukturer i cellen krävs ofta assistans från specialiserade enzymer som kallas för Hsp70-chaperoner. Hsp70-chaperoner utnyttjar energin i ATP-molekyler för att ...
Exploitation of an insect model to investigate nutrient controlled virulence of Candida albicans
Fungal infections are increasing and have serious consequences affecting the survival in the growing population of immuno-compromised patients, including those receiving chemotherapy and organ transplants, or infected with HIV. Candida albicans is the most common human fungal pathogen. C. albicans ...
Host-pathogen interaction systems as tools to identify antifungal targets in C. Albicans and C. Dubliniensis
One of the major tasks the Life Science industry faces in the coming years is to validate a plethora of targets for treatment of various diseases and the identification of novel lead compounds to generate novel pharmaceutics specifically acting on the targets identified. The “CanTrain” network will ...
Identification and regulation of genes important for B lymphocyte activation
B lymphocytes change adhesive and migratory properties and switch Immunoglobulin (Ig) class during activation by antigen in vivo. Similar responses occur when B cells are activated in vitro. I wish to identify proteins, which regulate the B cell morphology, by microarray analysis. Selected genes ...
Nutrient regulated gene expression II
Nutrient uptake is essential for life. We study the mechanisms of signal transduction that enable yeast cells to assess the availability of amino acids in their growth environment. The overall goal has been to use this model system to obtain precise and detailed mechanistic understanding of ...
Nutrient regulated gene expression in eukaryotic cells
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Karlsson, Roger, Prof
Ljungdahl, Per, Prof
Parmryd, Ingela, Dr
Severinson, Eva, Prof
Östlund Farrants, Ann-Kristin, Prof
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