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Developmental Biology (Wenner-Gren Institute)
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Göran Gustafsson Prize in Molecular Biology 2007
Integrering av signaler vid cellmigrering
Molecular dissection of airway maturation in Drosophila
Oxygen is vital for aerobic respiration and many animals evolved elaborate organs for its efficient transport and delivery to all cells in the body. Like our lungs and blood vessels, the tracheal airways deliver oxygen to all tissues of Drosophila and provide an excellent model system for the ...
Receptor tyrosine kinase signaling in Drosophila epithelial development and regeneration
Regulation of epithelial wound healing and airway maturation in Drosophila
Epithelial sheets provide barriers separating organs or entire organisms from their surroundings to regulate homeostasis. Epithelial cells are highly polarized to facilitate cell communication and transport of molecules across the apical and basolateral borders. One major aim of the project is to ...
Regulation of nucleocytoplasmic transport in Drosophila
The control of nucleocytoplasmic shuttling of gene regulators is a key aspect in the activation of signal transduction pathways. We have identified a complex of nuclear pore proteins, which tether the CRM1 export factor on the nuclear membrane and attenuate the rates of nuclear protein export. The ...
Regulators of epithelial wound healing in Drosophila
Wound healing and tissue repair is a fundamental property of multicellular organisms ranging from sponges to humans. Despite the medical importance of wound regeneration, progress in defining the signaling mechanisms initiating and orchestrating wound responses has been slow due to the complexity ...
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