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Physiology (Wenner-Gren Institute)
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Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue
Obesity represents the major risk factor for the cardiometabolic syndrome, which is an epidemic disease that generates a severe global socio-economic burden for the public health systems. Enhanced production of proinflammatory adipocytokines by expanded adipose tissue is now considered as a key ...
Brown adipose tissue and human obesity
Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes
The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and ...
The physiology of thermogenesis: acute and adaptive processes in brown adipose tissue
Brown adipose tissue is an organ unique to mammals, and is responsible for nonshivering thermogenesis. Central to an understanding of thermogenesis is an understanding of the mitochondrial uncoupling protein UCP1; regulation of its activity will be examined in-vitro and in knock-in mice with ...
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