Lidén, Göran (Atmospheric Science (Department of Applied Environmental Science)) http://su.avedas.com/converis/ws/public/feed/simple/atom/Person/1761/Contract 2012-12-18T14:21:46Z 2012-12-18T14:21:46Z Göran Lidén http://su.avedas.com/converis/contract/302 2012-12-18T14:18:39Z 2009-12-08T14:49:29Z

Due to their unique properties, engineered nanoparticles (ENP) are now used for a myriad of novel applications with great economic and technological importance. However, some of these properties, especially their surface reactivity, have raised health concerns, which have prompted scientists, regulators, and industry to seek consensus protocols for the safe production and use of the different forms of ENP. There is currently a shortage of field-worthy, cost-effective ways - especially in real time - for reliable assessment of exposure levels to ENP in workplace air. In addition to the problems with the size distribution, a major uncertainty in the safety assessment of airborne ENP arises from the lack of knowledge of their physical and chemical properties, and the levels of exposure. A special challenge of ENP monitoring is to separate ubiquitous background nanoparticles from different sources from the ENP. Here the main project goal is to develop innovative concepts and reliable methods for characterizing ENP in workplace air with novel, portable and easy-to-use devices suitable for workplaces. Additional research objectives are (1) identification of relevant physico-chemical properties and metrics of airborne ENP; establishment of reference materials; (2) exploring the association between physico-chemical and toxicological properties of ENP; (3) analyzing industrial processes as a source of ENP in workplace air; (4) developing methods for calibration and testing of the novel devices in real and simulated exposure situations; and (5) dissemination of the research results to promote the safe use of ENP through guidance, standards and education, implementing of safety objectives in ENP production and handling, and promotion of safety related collaborations through an international nanosafety platform.

Göran Lidén 2009-12-08T14:49:29Z Göran Lidén http://su.avedas.com/converis/contract/620 2012-12-18T14:18:59Z 2010-05-22T02:00:29Z

Mangan är ett metalliskt grundämne som kan vara skadligt i stora doser. Det förekommer bland annat i svetsrök. Svetsare är den yrkesgrupp som är mest utsatta för ämnet, som kan vara skadligt för hjärnan. Projektet undersöker hur, när och i vilka mängder svetsare utsätts för ämnet.

Göran Lidén 2010-05-22T02:00:29Z Karine Elihn, Göran Lidén http://su.avedas.com/converis/contract/4015 2012-12-18T14:21:46Z 2010-12-23T02:00:56Z

There is a great concern in the society about exposure to airborne metal particles due to the increasing use of engineered nanoparticles and remaining high contribution of unintentionally spread particles in the air. It is well-known today that airborne particles cause several different health effects, mainly upon inhalation. In this project, toxicity studies will be performed in new in vitro exposure systems that mimic a real inhalation scenario and airborne particles are deposited directly onto cells. Particle characteristics e.g. size, concentration, chemical composition, surface reactivity and metal release, influence the toxicity and will be thoroughly characterized. Today, the knowledge is sparse about how different particle characteristics affect the toxicity. By combining the exposure system with toxicity and surface reactivity studies of well-defined metallic particles relevant for real exposure scenarios, it is possible to generate an improved understanding of why particles can be harmful, with the ultimate goal to reduce adverse health effects from particles. An enhanced understanding of toxicity mechanisms through in vitro investigations will also enable the possibility of grouping metals with similar properties and allow read-across possibilities for risk- and hazard assessment and management. The benefit is a reduced need for animal testing of a vast amount of metal particles existing and developed for different applications on the market.

Karine Elihn, Göran Lidén 2010-12-23T02:00:56Z